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Ovarian epithelium regeneration by Lgr5+ cells

Nature Cell Biology volume 16, pages 743–744 (2014)Cite this article

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Lgr5, a marker of stem cells in many organs, is found expressed in cells scattered through the ovarian epithelium that expand to repair and regenerate the damaged ovarian surface after each ovulation. Lgr5-positive stem cells in the ovary and the fimbria of the oviduct may be critical cells of origin for ovarian cancer.

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Figure 1: Signals in fetal stages may establish the Lgr5+ population in the OSE and oviduct.

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  1. Department of Cell Biology, Duke University Medical Center, Durham, 27710, North Carolina, USA

    Blanche Capel

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  1. Blanche Capel
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Correspondence to Blanche Capel.

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Capel, B. Ovarian epithelium regeneration by Lgr5+ cells. Nat Cell Biol 16, 743–744 (2014). https://doi.org/10.1038/ncb3020

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