A growing role for Aurora A in chromosome instability

Chromosome instability is a major hallmark of cancer, but its molecular causes are still poorly understood. A study now describes how genetic alterations frequently found in colorectal cancer increase microtubule assembly rates during mitosis and promote chromosome instability.

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Figure 1: Chromosome instability in colorectal cancer induced by increased Aurora A activity.

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Correspondence to René H. Medema.

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Maia, A., van Heesbeen, R. & Medema, R. A growing role for Aurora A in chromosome instability. Nat Cell Biol 16, 739–741 (2014). https://doi.org/10.1038/ncb3018

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