Cell–cell interactions, a key feature of the stem cell niche, regulate many aspects of stem cell behaviour. N-cadherin-mediated anchorage of neural stem cells within the adult neural niche maintains stem cell quiescence, and its release by the metalloproteinase MT5-MMP promotes neural stem cell activation.
This is a preview of subscription content, access via your institution
Access options
References
Li, L. & Clevers, H. Science 327, 542–545 (2010).
Song, X., Zhu, C.-H., Doan, C. & Xie, T. Science 296, 1855–1857 (2002).
Inaba, M., Yuan, H., Salzmann, V., Fuller, M. T. & Yamashita, Y. M. PLoS One 5, e12473 (2010).
Li, P. & Zon, L. I. Cell Stem Cell 6, 199–202 (2010).
Porlan, E. et al. Nat. Cell Biol. 16, 629–638 (2014).
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M. & Alvarez-Buylla, A. Cell 97, 703–716 (1999).
Doetsch, F., Garcia-Verdugo, J. M. & Alvarez-Buylla, A. Proc. Natl. Acad. Sci. USA 96, 11619–11624 (1999).
Folgueras, A. R. et al. Proc. Natl. Acad. Sci. USA 106, 16451–16456 (2009).
Rago, L., Beattie, R., Taylor, V. & Winter, J. EMBO J. 33, 906–920 (2014).
Zhang, L., Yang, X., Yang, S. & Zhang, J. Eur. J. Neurosci. 33, 1–8 (2011).
Kawaguchi, D., Furutachi, S., Kawai, H., Hozumi, K. & Gotoh, Y. Nat. Commun. 4, 1880 (2013).
Kazanis, I. et al. J. Neurosci. 30, 9771–81 (2010).
Kokovay, E. et al. Cell Stem Cell 7, 163–73 (2010).
Carlén, M. et al. Nat. Neurosci. 12, 259–67 (2009).
Buczacki, S. J. A. et al. Nature 495, 65–9 (2013).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Long, K., ffrench-Constant, C. Neural stem cell quiescence comes to an un-sticky end. Nat Cell Biol 16, 625–627 (2014). https://doi.org/10.1038/ncb3003
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3003