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Retrograde flow of cadherins in collective cell migration

Nature Cell Biology volume 16, pages 621–623 (2014)Cite this article

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Collective cell migration is characterized by the maintenance of intercellular contacts during cell movement. The maintenance of N-cadherin-based junctions during collective migration is now shown to be facilitated by their treadmilling from the cell front to the rear, followed by N-cadherin endocytosis and recycling to the leading edge.

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Figure 1: Cycling of adherens junction (AJ) components during collective migration.

References

  1. Friedl, P., Locker, J., Sahai, E. & Segall, J. E. Nat. Cell Biol. 14, 777–783 (2012).

    Article  PubMed  Google Scholar 

  2. Meng, W. & Takeichi, M. Cold Spring Harb. Persp. Biol. 1, a002899 (2009).

    Google Scholar 

  3. Small, J. V. & Resch, G. P. Curr. Opin. Cell Biol. 17, 517–523 (2005).

    Article  CAS  PubMed  Google Scholar 

  4. Peglion, F., Llense, F. & Etienne-Manneville, S. Nat. Cell Biol. 16, 639–651 (2014).

    Article  CAS  PubMed  Google Scholar 

  5. Gnanaguru, G. et al. Development 140, 2050–2060 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Peng, H., Shah, W., Holland, P. & Carbonetto, S. Dev. Neurobiol. 68, 559–574 (2008).

    Article  CAS  PubMed  Google Scholar 

  7. Reffay, M. et al. Nat. Cell Biol. 16, 217–223 (2014).

    Article  CAS  PubMed  Google Scholar 

  8. Tambe, D. T. et al. Nat. Mater. 10, 469–475 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Hidalgo-Carcedo, C. et al. Nat. Cell Biol. 13, 49–58 (2011).

    Article  CAS  PubMed  Google Scholar 

  10. Theveneau, E. et al. Dev. Cell 19, 39–53 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Niessen, C. M. & Yap, A. S. Cell 127, 875–877 (2006).

    Article  CAS  PubMed  Google Scholar 

  12. Revenu, C. et al. Development 141, 1282–1291 (2014).

    Article  CAS  PubMed  Google Scholar 

  13. Ewald, A. J. et al. J. Cell Sci. 125, 2638–2654 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Roberts, B. J., Pashaj, A., Johnson, K. R. & Wahl, J. K. Exp. Cell Res. 317, 2814–2822 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Bridgewater, R. E., Norman, J. C. & Caswell, P. T. J. Cell Sci. 125, 3695–3701 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Kardash, E. et al. Nat. Cell Biol. 12, 47–53 (2010).

    Article  CAS  PubMed  Google Scholar 

  17. Niewiadomska, P., Godt, D. & Tepass, U. J. Cell Biol. 144, 533–547 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Eishu Hirata, Danielle Park and Erik Sahai are in the Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK,

    Eishu Hirata, Danielle Park & Erik Sahai

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  1. Eishu Hirata
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  2. Danielle Park
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  3. Erik Sahai
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E.H. and D.P. contributed equally to this work.

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Correspondence to Erik Sahai.

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The authors declare no competing financial interests.

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Hirata, E., Park, D. & Sahai, E. Retrograde flow of cadherins in collective cell migration. Nat Cell Biol 16, 621–623 (2014). https://doi.org/10.1038/ncb2995

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