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Retrograde flow of cadherins in collective cell migration

Nature Cell Biology volume 16, pages 621623 (2014) | Download Citation

Collective cell migration is characterized by the maintenance of intercellular contacts during cell movement. The maintenance of N-cadherin-based junctions during collective migration is now shown to be facilitated by their treadmilling from the cell front to the rear, followed by N-cadherin endocytosis and recycling to the leading edge.

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Author information

Affiliations

  1. Eishu Hirata, Danielle Park and Erik Sahai are in the Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK

    • Eishu Hirata
    • , Danielle Park
    •  & Erik Sahai

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Contributions

E.H. and D.P. contributed equally to this work.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Erik Sahai.

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DOI

https://doi.org/10.1038/ncb2995

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