Pluripotent embryonic stem cells (ESCs) can be derived from blastocyst-stage mouse embryos. However, the exact in vivo counterpart of ESCs has remained elusive. A combination of expression profiling and stem cell derivation identifies epiblast cells from late-stage blastocysts as the source, and functional equivalent, of ESCs.
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Plusa, B., Hadjantonakis, AK. Embryonic stem cell identity grounded in the embryo. Nat Cell Biol 16, 502–504 (2014). https://doi.org/10.1038/ncb2984
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DOI: https://doi.org/10.1038/ncb2984
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