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Life without the mitochondrial calcium uniporter

Nature Cell Biology volume 15, pages 13981400 (2013) | Download Citation

Calcium enters mitochondria through a dedicated channel referred to as the mitochondrial calcium uniporter (MCU), whose molecular identity has long remained elusive. Since the discovery of the gene encoding the MCU protein two years ago, researchers have awaited the generation of a mouse lacking the MCU. These mice are fully viable and show defects limited to performance of high-energy-demanding exercises. Strikingly, no protection against necrosis is observed following ischaemia-reperfusion in the heart.

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Affiliations

  1. Sébastien Herzig, Kinsey Maundrell and Jean-Claude Martinou Martinou are in the Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland

    • Sébastien Herzig
    • , Kinsey Maundrell
    •  & Jean-Claude Martinou

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Jean-Claude Martinou.

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DOI

https://doi.org/10.1038/ncb2891

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