Abstract
Cilia are present across most eukaryotic phyla and have diverse sensory and motility roles in animal physiology, cell signalling and development. Their biogenesis and maintenance depend on vesicular and intraciliary (intraflagellar) trafficking pathways that share conserved structural and functional modules. The functional units of the interconnected pathways, which include proteins involved in membrane coating as well as small GTPases and their accessory factors, were first experimentally associated with canonical vesicular trafficking. These components are, however, ancient, having been co-opted by the ancestral eukaryote to establish the ciliary organelle, and their study can inform us about ciliary biology in higher organisms.
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Acknowledgements
The field of cilium trafficking has grown tremendously in the last few years and the authors apologize for not covering all relevant studies due to space restrictions. M.R.L. acknowledges funding from the Canadian Institutes of Health Research (CIHR; grant MOP-123527) and a senior scholar award from Michael Smith Foundation for Health Research (MSFHR). C.H.S. is funded by NIH-EY11307, NIH-EY016805, Research To Prevent Blindness, and Starr Stem Cell Foundation.
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Sung, CH., Leroux, M. The roles of evolutionarily conserved functional modules in cilia-related trafficking. Nat Cell Biol 15, 1387–1397 (2013). https://doi.org/10.1038/ncb2888
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DOI: https://doi.org/10.1038/ncb2888
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