Cytoplasmic compartments containing misfolded proteins targeted for degradation, named Q-bodies, have been identified. Q-body formation is a dynamic process that actively manages the metastable state of the protein fold through small heat shock proteins and the Hsp70–Hsp90–Hsp110 proteostasis system to promote cellular fitness under both physiological and stress conditions.
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Roth, D., Balch, W. Q-bodies monitor the quinary state of the protein fold. Nat Cell Biol 15, 1137–1139 (2013). https://doi.org/10.1038/ncb2857
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DOI: https://doi.org/10.1038/ncb2857
