The role of RNA splicing in the regulation of stem cell properties has remained largely unexplored. The splicing-associated protein SON is now shown to be necessary for embryonic stem cell maintenance, by influencing the splicing of pluripotency regulators.
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Livyatan, I., Meshorer, E. SON sheds light on RNA splicing and pluripotency. Nat Cell Biol 15, 1139–1140 (2013). https://doi.org/10.1038/ncb2851
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DOI: https://doi.org/10.1038/ncb2851
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