Swapping CENP-A at the centromere

Faithful genome segregation depends on the functions of the eukaryotic centromere, which is characterized by the histone variant CENP-A. Gene replacement in human cells and fission yeast has now been used to show how CENP-A biochemically encodes centromere identity, as well as reveal an unexpected role for CENP-B in centromere function.

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Figure 1: Three functional domains comprise the centromere-specific histone, CENP-A (red).

References

  1. 1

    Rop, V., Padeganeh, A. & Maddox, P. S. Chromosoma 121, 527–538 (2012).

  2. 2

    Burrack, L. S. & Berman, J. Chromosome Res. 20, 607–619 (2012).

  3. 3

    Howman, E. V. et al. Proc. Natl Acad. Sci. USA 97, 1148–1153 (2000).

  4. 4

    Black, B. E. et al. Mol. Cell 25, 309–322 (2007).

  5. 5

    Fachinetti, D. et al. Nat. Cell Biol. 15, 1056–1066 (2013).

  6. 6

    Ohzeki, J., Nakano, M., Okada, T. & Masumoto, H. J. Cell Biol. 159, 765–775 (2002).

  7. 7

    Guse, A., Carroll, C. W., Moree, B., Fuller, C. J. & Straight, A. F. Nature 477, 354–358 (2011).

  8. 8

    Liu, S. T., Rattner, J. B., Jablonski, S. A. & Yen, T. J. J. Cell Biol. 175, 41–53 (2006).

  9. 9

    Black, B. E. et al. Nature 430, 578–582 (2004).

  10. 10

    Foltz, D. R. et al. Cell 137, 472–484 (2009).

  11. 11

    Carroll, C. W., Silva, M. C., Godek, K. M., Jansen, L. E. & Straight, A. F. Nat. Cell Biol. 11, 896–902 (2009).

  12. 12

    Carroll, C. W., Milks, K. J. & Straight, A. F. J. Cell Biol. 189, 1143–1155 (2010).

  13. 13

    Kato, H. et al. Science 340, 1110–1113 (2013).

  14. 14

    Muro, Y. et al. J. Cell Biol. 116, 585–596 (1992).

  15. 15

    Masumoto, H., Nakano, M. & Ohzeki, J. Chromosome Res. 12, 543–556 (2004).

  16. 16

    Okada, T. et al. Cell 131, 1287–1300 (2007).

  17. 17

    Gaj, T., Gersbach, C. A. & Barbas, C. F. Trends Biotechnol. 31, 397–405 (2013).

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Correspondence to Aaron F. Straight.

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French, B., Straight, A. Swapping CENP-A at the centromere. Nat Cell Biol 15, 1028–1030 (2013). https://doi.org/10.1038/ncb2833

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