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Linking HSCs to their youth

Nature Cell Biology volume 15, pages 885887 (2013) | Download Citation

  • An Erratum to this article was published on 02 September 2013

This article has been updated

Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated to boost the lower self-renewal activity of quiescent adult HSCs.

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  • 02 August 2013

    In the version of this News and Views originally published, there was an error in Fig. 1: the blue cell on the right should have been labelled ‘Adult HSC’, not ‘Fetal HSC’. This has been corrected in the HTML and PDF versions.

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Author information

Affiliations

  1. Eric M. Pietras and Emmanuelle Passegué are at the The Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, 35 Medical Center Way, RMB 1017, San Francisco, California, USA

    • Eric M. Pietras
    •  & Emmanuelle Passegué

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Emmanuelle Passegué.

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DOI

https://doi.org/10.1038/ncb2817

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