Common fragile sites (CFSs) are chromosomal regions that are prone to form breaks or gaps during mitosis, in particular following replication stress. The mechanisms modulating CFS expression and promoting safe chromatid transmission to daughter cells are not clear. Now CFS expression is shown to reflect the activity of the MUS81–EME1 resolvase complex which cooperates with the dissolving action of the BLM helicase to prevent uncontrolled chromosome breakage and to promote genome integrity.
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References
Durkin, S. G. & Glover, T. W. Annu. Rev. Genet. 41, 169–192 (2007).
Ying, S. et al. Nat. Cell Biol. 15, 1001–1007 (2013).
Naim, V., Wilhelm, T., Debatisse, M. & Rosselli, F. Nat. Cell Biol. 15, 1008–1015 (2013).
Debatisse, M., Le Tallec, B., Letessier, A., Dutrillaux, B. & Brison, O. Trends Genet. 28, 22–32 (2012).
Schwartz, M., Zlotorynski, E. & Kerem, B. Cancer Lett. 232, 13–26 (2006).
Ozeri-Galai, E. et al. Mol. Cell 43, 122–131 (2011).
Letessier, A. et al. Nature 470, 120–123 (2011).
Helmrich, A., Ballarino, M. & Tora, L. Mol. Cell 44, 966–977 (2011).
Pirzio, L. M., Pichierri, P., Bignami, M. & Franchitto, A. J. Cell Biol. 180, 305–314 (2008).
Casper, A. M., Nghiem, P., Arlt, M. F. & Glover, T. W. Cell 111, 779–789 (2002).
Chan, K. L., North, P. S. & Hickson, I. D. EMBO J. 26, 3397–3409 (2007).
Kai, M., Boddy, M. N., Russell, P. & Wang, T. S. F. Genes Dev. 19, 919–932 (2005).
Gallo-Fernández, M., Saugar, I., Ortiz-Bazán, M. Á., Vázquez, M. V. & Tercero, J. A. Nucleic Acids Res. 40, 8325–8335 (2012).
Lukas, C. et al. Nat. Cell Biol. 13, 243–253 (2011).
Harrigan, J. A. et al. J. Cell Biol. 193, 97–108 (2011).
Granata, M. et al. Cell Cycle 12, 1848–1860 (2013).
Muñoz, I. M. et al. Mol. Cell 35, 116–127 (2009).
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Pellicioli, A., Muzi-Falconi, M. A blooming resolvase at chromosomal fragile sites. Nat Cell Biol 15, 883–885 (2013). https://doi.org/10.1038/ncb2812
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DOI: https://doi.org/10.1038/ncb2812