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Polycomb complex recruitment in pluripotent stem cells

The recruitment of the silencing complex Polycomb group (PcG) to its target sites in mammalian cells has remained elusive. A prevalent model proposes that the PRC1 component is recruited through recognition of methylated H3K27 found at target sites occupied by the PRC2 component. However, mounting evidence suggests that PRC2-independent mechanisms of PRC1 recruitment exist. Three studies describe that the histone demethylase Kdm2b binds to unmethylated CpG islands and recruits a subset of PRC1 complexes to chromatin in pluripotent stem cells.

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Figure 1: Differences in subunit composition of PRC1 complexes account for different recruitment mechanisms.


  1. Lewis, E. B. Nature 276, 565–570 (1978).

    Article  CAS  Google Scholar 

  2. Simon, J. A. & Kingston, R. E. Nat. Rev. Mol. Cell Biol. 10, 697–708 (2009).

    Article  CAS  Google Scholar 

  3. Pasini, D. et al. Nature 464, 306–310 (2010).

    Article  CAS  Google Scholar 

  4. Rinn, J. L. et al. Cell 129, 1311–1323 (2007).

    Article  CAS  Google Scholar 

  5. Cao, R. et al. Science 298, 1039–1043 (2002).

    Article  CAS  Google Scholar 

  6. Min, J., Zhang, Y. & Xu, R. M. Genes Dev. 17, 1823–1828 (2003).

    Article  CAS  Google Scholar 

  7. Tanay, A. & O'Donnell, A. H. Proc. Natl Acad. Sci. USA 104, 5521–5526 (2007).

    Article  CAS  Google Scholar 

  8. Ku, M. et al. PLoS Genet. 4, e1000242 (2008).

    Article  Google Scholar 

  9. Gao, Z. et al. Mol. Cell 45, 344–356 (2012).

    Article  CAS  Google Scholar 

  10. Tavares, L. et al. Cell 148, 664–678 (2012).

    Article  CAS  Google Scholar 

  11. He, J. et al. Nat. Cell Biol. 15, 373–384 (2013).

    Article  CAS  Google Scholar 

  12. Farcas, A. M. et al. eLife 1, e00205 (2012).

    Article  Google Scholar 

  13. Wu, X., Johansen, J. V. & Helin, K. Mol. Cell (2013).

  14. Liang, G., He, J. & Zhang, Y. Nat. Cell Biol. 14, 457–466 (2011).

    Article  Google Scholar 

  15. Voo, K. S., Carlone, D. L., Jacobsen, B. M., Flodin, A. & Skalnik, D. G. Mol. Cell. Biol. 20, 2108–2121 (2000).

    Article  CAS  Google Scholar 

  16. Jones, P. A. & Baylin, S. B. Cell 128, 683–692 (2007).

    Article  CAS  Google Scholar 

  17. Fischle, W. et al. Genes Dev. 17, 1870–1881 (2003).

    Article  CAS  Google Scholar 

  18. Qin, J. et al. Cell Stem Cell 11, 319–332 (2012).

    Article  CAS  Google Scholar 

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Correspondence to Juan Carlos Izpisua Belmonte.

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Barrero, M., Belmonte, J. Polycomb complex recruitment in pluripotent stem cells. Nat Cell Biol 15, 348–350 (2013).

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