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Cullin' PLK1 from kinetochores

Nature Cell Biology volume 15, pages 347348 (2013) | Download Citation

To ensure proper attachment of all chromosomes to the spindle, PLK1 has to associate with kinetochores during prometaphase and must be released from these sites before sister chromatid separation can begin. The monoubiquitylation of PLK1 by the ubiquitin ligase CUL3–KLHL22 is now identified as a critical step in promoting the release of PLK1 from kinetochores, pushing non-proteolytic ubiquitylation into the limelight of cell division research.

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Author information

Affiliations

  1. Colleen A. McGourty and Michael Rape are in the Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA

    • Colleen A. McGourty
    •  & Michael Rape

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Michael Rape.

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DOI

https://doi.org/10.1038/ncb2722

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