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Cullin' PLK1 from kinetochores

Nature Cell Biology volume 15, pages 347–348 (2013)Cite this article

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To ensure proper attachment of all chromosomes to the spindle, PLK1 has to associate with kinetochores during prometaphase and must be released from these sites before sister chromatid separation can begin. The monoubiquitylation of PLK1 by the ubiquitin ligase CUL3–KLHL22 is now identified as a critical step in promoting the release of PLK1 from kinetochores, pushing non-proteolytic ubiquitylation into the limelight of cell division research.

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Figure 1: Monoubiquitylation triggers PLK1 dissociation from kinetochores.

References

  1. Lens, S. M., Voest, E. E. & Medema, R. H. Nat. Rev. Cancer 10, 825–841 (2010).

    Article  CAS  Google Scholar 

  2. Elia, A. E., Cantley, L. C. & Yaffe, M. B. Science 299, 1228–1231 (2003).

    Article  CAS  Google Scholar 

  3. Suijkerbuijk, S. J., Vleugel, M., Teixeira, A. & Kops, G. J. Dev. Cell 23, 745–755 (2012).

    Article  CAS  Google Scholar 

  4. Elowe, S., Hummer, S., Uldschmid, A., Li, X. & Nigg, E. A. Genes Dev. 21, 2205–2219 (2007).

    Article  CAS  Google Scholar 

  5. Musacchio, A. & Salmon, E. D. Nat. Rev. Mol. Cell Biol. 8, 379–393 (2007).

    Article  CAS  Google Scholar 

  6. Liu, D., Davydenko, O. & Lampson, M. A. J. Cell Biol. 198, 491–499 (2012).

    Article  CAS  Google Scholar 

  7. Beck, J. et al. Nat. Cell Biol. 15, 430–439 (2013).

    Article  CAS  Google Scholar 

  8. Maerki, S. et al. J. Cell Biol. 187, 791–800 (2009).

    Article  CAS  Google Scholar 

  9. Williamson, A., Werner, A. & Rape, M. Mol. Cell 49, 591–600 (2013).

    Article  CAS  Google Scholar 

  10. Kim, W. et al. Mol. Cell 44, 325–340 (2011).

    Article  CAS  Google Scholar 

  11. Wagner, S. A. et al. Mol. Cell. Proteomics 10, M111.013284 (2011).

    Article  Google Scholar 

  12. Elia, A. E. et al. Cell 115, 83–95 (2003).

    Article  CAS  Google Scholar 

  13. Hanks, S. et al. Nat. Genet. 36, 1159–1161 (2004).

    Article  CAS  Google Scholar 

  14. Jin, L. et al. Nature 482, 495–500 (2012).

    Article  CAS  Google Scholar 

  15. Liu, D. et al. J. Cell. Biol. 188, 809–820 (2010).

    Article  CAS  Google Scholar 

Download references

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  1. Colleen A. McGourty and Michael Rape are in the Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA,

    Colleen A. McGourty & Michael Rape

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  1. Colleen A. McGourty
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  2. Michael Rape
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Correspondence to Michael Rape.

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The authors declare no competing financial interests.

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McGourty, C., Rape, M. Cullin' PLK1 from kinetochores. Nat Cell Biol 15, 347–348 (2013). https://doi.org/10.1038/ncb2722

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