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Formin' cables under stress

Nature Cell Biology volume 15, pages 345346 (2013) | Download Citation

How application of force affects actin remodelling during mechanotransduction has remained unclear. Mechanical manipulation of the cell cortex is now shown to trigger actin monomer release from filaments, which in turn activates formin-dependent actin filament elongation. This force-sensitive actin polymerization does not require GTPases or membrane receptors, but it involves actin itself.

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References

  1. 1.

    , & Nat. Rev. Mol. Cell Biol. 10, 21–33 (2009).

  2. 2.

    et al. Eur. J. Cell. Biol. 85, 165–173 (2006).

  3. 3.

    et al. Nat. Cell Biol. 15, 395–405 (2013).

  4. 4.

    Trends Cell Biol. 14, 589–593 (2004).

  5. 5.

    et al. Science 303, 2007–2010 (2004).

  6. 6.

    & Curr. Biol. 18, 9–19 (2008).

  7. 7.

    & Cell Motil. Cytoskel. 66, 606–617 (2009).

  8. 8.

    & Curr. Biol. 13, 1335–1340 (2003).

  9. 9.

    , , & EMBO J. 24, 4176–4187 (2005).

  10. 10.

    & Nat. Rev. Mol. Cell Biol. 11, 237–251 (2010).

  11. 11.

    et al. Nature 435, 513–518 (2005).

  12. 12.

    & J. Cell Biol. 167, 1011–1017 (2004).

  13. 13.

    et al. J. Cell Sci. 121, 3403–3412 (2008).

  14. 14.

    , , , & Bioarchitecture 1, 240–244 (2011).

  15. 15.

    , , & J. Cell Biol. 193, 365–380 (2011).

Download references

Author information

Affiliations

  1. Deborah Leckband is in the Department of Chemical and Biomolecular Engineering, Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA

    • Deborah Leckband

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Deborah Leckband.

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DOI

https://doi.org/10.1038/ncb2715

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