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Endocytosis regulates VEGF signalling during angiogenesis

Nature Cell Biology volume 15, pages 233–235 (2013)Cite this article

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Endocytosis has proved to be a versatile mechanism regulating diverse cellular processes, ranging from nutrient uptake to intracellular signal transduction. New work reinforces the importance of endocytosis for VEGF receptor signalling and angiogenesis in the developing eye, and describes a mechanism for its differential regulation in angiogenic versus quiescent endothelial cells.

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Figure 1: Schematic representation of VEGFR endocytosis and signalling.

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Authors and Affiliations

  1. Konstantin Gaengel and Christer Betsholtz are in the Department of Immunology, and the Department of Medical Biochemistry and Biophysics, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden, Karolinska Institutet, Stockholm, Sweden,

    Konstantin Gaengel & Christer Betsholtz

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  1. Konstantin Gaengel
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  2. Christer Betsholtz
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Correspondence to Christer Betsholtz.

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The authors declare no competing financial interests.

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Gaengel, K., Betsholtz, C. Endocytosis regulates VEGF signalling during angiogenesis. Nat Cell Biol 15, 233–235 (2013). https://doi.org/10.1038/ncb2705

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