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A one-two punch of miR-126/126* against metastasis


MicroRNAs regulate cancer metastasis by modulating both the intrinsic properties of tumour cells and their interactions with the tumour stroma. Both strands of the miR-126/miR-126* duplex are now shown to simultaneously target the Sdf-1α cytokine to reduce the recruitment of mesenchymal stem cells and inflammatory monocytes to primary tumours, thereby inhibiting lung metastasis.

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Figure 1: Multiple roles of miR-126/126* in breast cancer metastasis.


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Correspondence to Yibin Kang.

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Ren, G., Kang, Y. A one-two punch of miR-126/126* against metastasis. Nat Cell Biol 15, 231–233 (2013).

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