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'Goldilocks' suppressor screen identifies web of polarity regulators

Nature Cell Biology volume 15, pages 9–10 (2013)Cite this article

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Genome sequencing and RNAi have been powerful allies in the quest to assign function to every gene. Systematic RNAi screens identify essential genes efficiently, but are less effective with pleiotropic or redundant genes. A common trick used by geneticists to overcome this problem is to screen for genetic interactors — mutations that enhance or suppress the phenotype of a starting mutation. Now, this classic approach has been combined with the versatility of RNAi to generate an expanded gene network for cell polarity.

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Figure 1: Simplified model for polarization of the C. elegans zygote.

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Authors and Affiliations

  1. Geraldine Seydoux is in the Department of Molecular Biology and Genetics, HHMI, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA,

    Geraldine Seydoux

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  1. Geraldine Seydoux
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Correspondence to Geraldine Seydoux.

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The author declares no competing financial interests.

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Seydoux, G. 'Goldilocks' suppressor screen identifies web of polarity regulators. Nat Cell Biol 15, 9–10 (2013). https://doi.org/10.1038/ncb2666

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