Brown adipose tissue is intensively researched owing to its role in regulating energy and glucose homeostasis. Its differentiation is controlled through adrenergic-dependent regulation of the transcriptional co-regulator Prdm16. Adrenergic stimulation inhibits expression of miR-133a/b in a Mef2c-dependent manner to abrogate post-transcriptional silencing of Prdm16.
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Kornfeld, JW., Brüning, J. MyomiRs-133a/b turn off the heat. Nat Cell Biol 14, 1248–1249 (2012). https://doi.org/10.1038/ncb2642
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DOI: https://doi.org/10.1038/ncb2642