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MyomiRs-133a/b turn off the heat

Nature Cell Biology volume 14, pages 12481249 (2012) | Download Citation

Brown adipose tissue is intensively researched owing to its role in regulating energy and glucose homeostasis. Its differentiation is controlled through adrenergic-dependent regulation of the transcriptional co-regulator Prdm16. Adrenergic stimulation inhibits expression of miR-133a/b in a Mef2c-dependent manner to abrogate post-transcriptional silencing of Prdm16.

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Author information

Affiliations

  1. Jan-Wilhelm Kornfeld and Jens C. Brüning are at the Max Planck Institute for Neurological Research, Gleueler Street 50a, 50931 Köln, Germany, and the Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Zülpicher Street 47a, 50674 Köln, Germany

    • Jan-Wilhelm Kornfeld
    •  & Jens C. Brüning

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Jens C. Brüning.

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DOI

https://doi.org/10.1038/ncb2642

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