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Hippo–YAP and mTOR pathways collaborate to regulate organ size

Nature Cell Biology volume 14, pages 12441245 (2012) | Download Citation

Regulation of organ size is achieved through the action of the mTOR and Hippo signalling pathways, which control cell proliferation and cell growth in response to extracellular cues. A link between these pathways is revealed by the finding that YAP downregulates PTEN to promote cell growth and tissue hyperplasia.

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Author information

Affiliations

  1. Alfred Csibi and John Blenis are in the Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, 02115 Massachusetts. USA

    • Alfred Csibi
    •  & John Blenis

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to John Blenis.

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DOI

https://doi.org/10.1038/ncb2634

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