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Stem cell reprogramming as a driver of basal cell carcinoma

Nature Cell Biology volume 14, pages 12461247 (2012) | Download Citation

Basal cell carcinoma has been shown to originate from activation of hedgehog signalling in interfollicular epidermal progenitor cells. Analyses of the early steps of basal cell carcinoma formation show that this process requires reprogramming of interfolliclular epidermal cells to an embryonic hair follicle progenitor-like fate, with concomitant Wnt pathway activation.

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Affiliations

  1. David W. M. Tan and Nick Barker are at the Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648 Singapore

    • David W. M. Tan
    •  & Nick Barker

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Nick Barker.

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DOI

https://doi.org/10.1038/ncb2631

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