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Stem cell reprogramming as a driver of basal cell carcinoma

Nature Cell Biology volume 14, pages 1246–1247 (2012)Cite this article

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Basal cell carcinoma has been shown to originate from activation of hedgehog signalling in interfollicular epidermal progenitor cells. Analyses of the early steps of basal cell carcinoma formation show that this process requires reprogramming of interfolliclular epidermal cells to an embryonic hair follicle progenitor-like fate, with concomitant Wnt pathway activation.

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Figure 1: Steps leading to BCC initiation and development.

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Authors and Affiliations

  1. David W. M. Tan and Nick Barker are at the Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648 Singapore,

    David W. M. Tan & Nick Barker

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  1. David W. M. Tan
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  2. Nick Barker
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Correspondence to Nick Barker.

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The authors declare no competing financial interests.

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Tan, D., Barker, N. Stem cell reprogramming as a driver of basal cell carcinoma. Nat Cell Biol 14, 1246–1247 (2012). https://doi.org/10.1038/ncb2631

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