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Setting Snail2's pace during EMT

Nature Cell Biology volume 14, pages 11221123 (2012) | Download Citation

Epithelial to mesenchymal transition (EMT) is a fundamental process in both development and cancer progression. The transcription factor Elf5 is now reported as an upstream regulator of the key EMT inducer Snail2, and is shown to regulate the earliest known rewiring events required for tumour cell invasiveness and metastasis.

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Author information

Affiliations

  1. Haritha Mathsyaraja is in the Molecular, Cellular and Developmental Biology Program, Ohio State University, and the OSU Comprehensive Cancer Center, Columbus, Ohio, USA

    • Haritha Mathsyaraja
  2. Michael C. Ostrowski is in the Department of Molecular and Cellular Biochemistry, Ohio State University, and the OSU Comprehensive Cancer Center, Columbus, Ohio, USA

    • Michael C. Ostrowski

Authors

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Michael C. Ostrowski.

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DOI

https://doi.org/10.1038/ncb2616

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