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Setting Snail2's pace during EMT

Nature Cell Biology volume 14, pages 1122–1123 (2012)Cite this article

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Epithelial to mesenchymal transition (EMT) is a fundamental process in both development and cancer progression. The transcription factor Elf5 is now reported as an upstream regulator of the key EMT inducer Snail2, and is shown to regulate the earliest known rewiring events required for tumour cell invasiveness and metastasis.

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Figure 1: Elf5 function in mammary gland development and breast cancer.

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Authors and Affiliations

  1. Haritha Mathsyaraja is in the Molecular, Cellular and Developmental Biology Program, Ohio State University, and the OSU Comprehensive Cancer Center, Columbus, Ohio, USA,

    Haritha Mathsyaraja

  2. Michael C. Ostrowski is in the Department of Molecular and Cellular Biochemistry, Ohio State University, and the OSU Comprehensive Cancer Center, Columbus, Ohio, USA,

    Michael C. Ostrowski

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  1. Haritha Mathsyaraja
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  2. Michael C. Ostrowski
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Correspondence to Michael C. Ostrowski.

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The authors declare no competing financial interests.

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Mathsyaraja, H., Ostrowski, M. Setting Snail2's pace during EMT. Nat Cell Biol 14, 1122–1123 (2012). https://doi.org/10.1038/ncb2616

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