Epithelial to mesenchymal transition (EMT) is a fundamental process in both development and cancer progression. The transcription factor Elf5 is now reported as an upstream regulator of the key EMT inducer Snail2, and is shown to regulate the earliest known rewiring events required for tumour cell invasiveness and metastasis.
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Mathsyaraja, H., Ostrowski, M. Setting Snail2's pace during EMT. Nat Cell Biol 14, 1122–1123 (2012). https://doi.org/10.1038/ncb2616
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DOI: https://doi.org/10.1038/ncb2616
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