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Atypical E2Fs drive atypical cell cycles

It is well documented that polyploid cells exist in mammalian tissues such as the placenta and liver, but their function and the mechanisms for their formation have remained elusive. Two studies now identify a role for atypical E2F transcription factors in promoting polyploidy in mammals and challenge present theories about the function of polyploidy.

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Figure 1: Endoreplication is regulated by E2F transcription factors.

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Correspondence to Robert J. Duronio.

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Meserve, J., Duronio, R. Atypical E2Fs drive atypical cell cycles. Nat Cell Biol 14, 1124–1125 (2012). https://doi.org/10.1038/ncb2609

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