Vascular endothelial growth factor (VEGF) signalling induces embryonic vascular development and angiogenesis in adult tissues. Direct phosphorylation of the actin-binding protein profilin by VEGF receptors is now shown to increase its affinity for actin, and to be essential for adult but not embryonic arteriogenesis.
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Simons, M., Schwartz, M. Profilin phosphorylation as a VEGFR effector in angiogenesis. Nat Cell Biol 14, 985–987 (2012). https://doi.org/10.1038/ncb2596
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DOI: https://doi.org/10.1038/ncb2596
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