Lilly, M. A. & Duronio, R. J. New insights into cell cycle control from the Drosophila endocycle. Oncogene 24, 2765–2775 (2005).
Varmuza, S., Prideaux, V., Kothary, R. & Rossant, J. Polytene chromosomes in mouse trophoblast giant cells. Development 102, 127–134 (1988).
Cross, J. How to make a placenta: mechanisms of trophoblast cell differentiation in mice—a review. Placenta 26, S3–S9 (2005).
Mehrotra, S., Maqbool, S. B., Kolpakas, A., Murnen, K. & Calvi, B. R. Endocycling cells do not apoptose in response to DNA rereplication genotoxic stress. Gen. Dev. 22, 3158–3171 (2008).
Lee, H. O., Davidson, J. M. & Duronio, R. J. Endoreplication: polyploidy with purpose. Gen. Dev. 23, 2461–2477 (2009).
Storchova, Z. & Pellman, D. From polyploidy to aneuploidy, genome instability and cancer. Nat. Rev. Mol. Cell. Biol. 5, 45–54 (2004).
Harbour, J. W. & Dean, D. C. The Rb/E2F pathway: expanding roles and emerging paradigms. Gen. Dev. 14, 2393–2409 (2000).
Yamasaki, L. et al. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85, 537–548 (1996).
Field, S. J. et al. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85, 549–561 (1996).
Humbert, P. O. et al. E2f3 is critical for normal cellular proliferation. Gen. Dev. 14, 690–703 (2000).
Murga, M. et al. Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity 15, 959–970 (2001).
Humbert, P. O. et al. E2F4 is essential for normal erythrocyte maturation and neonatal viability. Mol. Cell 6, 281–91 (2000).
Rempel, R. E. et al. Loss of E2F4 activity leads to abnormal development of multiple cellular lineages. Mol. Cell 6, 293–306 (2000).
Lindeman, G. J. et al. A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Gen. Dev. 12, 1092–1098 (1998).
Pohlers, M. et al. A role for E2F6 in the restriction of male-germ-cell-specific gene expression. Curr. Biol. 15, 1051–1057 (2005).
Li, J. et al. Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev. Cell 14, 62–75 (2008).
Chen, H-Z., Tsai, S-Y. & Leone, G. Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat. Rev. Cancer 9, 785–797 (2009).
Trimarchi, J. M. & Lees, J. A. Sibling rivalry in the E2F family. Nat. Rev. Mol. Cell Biol. 3, 11–20 (2002).
Lammens, T., Li, J., Leone, G. & De Veylder, L. Atypical E2Fs: new players in the E2F transcription factor family. Trends Cell Biol. 19, 111–118 (2009).
Breuer, C., Ishida, T. & Sugimoto, K. Developmental control of endocycles and cell growth in plants. Curr. Opin. Plant Biol. 13, 654–660 (2010).
Zielke, N. et al. Control of Drosophila endocycles by E2F and CRL4(CDT2). Nature 480, 123–127 (2011).
Barbason, H., Van Cantfort, J. & Houbrechts, N. Correlation between tissular and division functions in the liver of young rats. Cell Tissue Kinet. 7, 319–326 (1974).
Dallman, P. R., Spirito, R. A. & Siimes, M. A. Diurnal patterns of DNA synthesis in the rat: modification by diet and feeding schedule. J. Nutr. 104, 1234–1241 (1974).
Tsai, S-Y. et al. Mouse development with a single E2F activator. Nature 454, 1137–1141 (2008).
Chong, J-L. et al. E2f1–3 switch from activators in progenitor cells to repressors in differentiating cells. Nature 462, 930–934 (2009).
Wenzel, P. et al. Cell proliferation in the absence of E2F1-3. Dev. Biol. 351, 35–45 (2010).
Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice.
Science 8, 1427–1429 (1995).
de Bruin, A. et al. Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. J. Biol. Chem. 278, 42041–42049 (2003).
Di Stefano, L. et al. E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J. 22, 6289–6298 (2003).
Maiti, B. et al. Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. J. Biol. Chem. 280, 18211–18220 (2005).
Christensen, J. et al. Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Nucleic Acids Res. 33, 5458–5470 (2005).
Ouseph, M. M. et al. Atypical E2F repressors and activators coordinate placental development. Dev. Cell 22, 849–862 (2012).
Postic, C. & Magnuson, M. A. DNA excision in liver by an albumin-cre transgene occurs progressively with age. Genesis 26, 149–150 (2000).
Margall-Ducos, G., Celton-Morizur, S., Couton, D., Bregerie, O. & Desdouets, C. Liver tetraploidization is controlled by a new process of incomplete cytokinesis. J. Cell Sci. 120, 3633–3639 (2007).
Schuler, M., Dierich, A., Chambon, P & Metzger, D. Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse. Genesis 39, 167–172 (2004).
Normand, G. & King, R. W. Understanding cytokinesis failure. Adv. Exp. Med. Biol. 676, 27–55 (2010).
Ullah, Z., Lee, C. Y., Lilly, M. A. & DePamphilis, M. L. Developmentally programmed endoreduplication in animals. Cell Cycle 8, 1501–1509 (2009).
Sorensen, C. S. et al. A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression. Mol. Cell. Biol. 21, 3692–3703 (2001).
Kalaszczynska, I. et al. Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell 138, 352–365 (2009).
Edgar, B. A. & Orr-Weaver, T. L. Endoreplication cell cycles: more for less. Cell 105, 297–306 (2001).
Inzé, D. & De Veylder, L. Cell cycle regulation in plant development. Annu. Rev. Genet. 40, 77–105 (2006).
Duronio, R. J., O’Farrell, P. H., Xie, J. E., Brook, A. & Dyson, N. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Gen. Dev. 9, 1445–1455 (1995).
Weng, L., Zhu, C., Xu, J. & Du, W. Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J. 22, 3865–3875 (2003).
Lammens, T. et al. Atypical E2F activity restrains APC/CCCS52A2 functionobligatory for endocycle onset. Proc. Natl Acad. Sci. USA 105, 14721–14726 (2008).
Kohn, M. J., Bronson, R. T., Harlow, E., Dyson, N. J. & Yamasaki, L. Dp1 is required for extra-embryonic development. Development 130, 1295–1305 (2003).
Krek, W. et al. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78, 161–172 (1994).
Krek, W. et al. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell 83, 1149–1158 (1995).
Hardie, D. C., Gregory, T. R. & Hebert, P. D. From pixels to picograms: a beginners’ guide to genome quantification by Feulgen image analysis densitometry. J. Histochem. Cytochem. 50, 735–749 (2002).
Mayhew, C. N. et al. Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. Cancer Res. 65, 4568–4577 (2005).
Irizarry, R. A. et al. Summaries of Affymetrix GeneChip probe level data. Nucl. Acids Res. 31, 1–8 (2003).
Bolstad, B. M., Irizarry, R. A., Astrand, M. & Speed, T. P. A Comparison of normalization methods for high density oligonucleotide array data based on bias and variance. Bioinformatics 19, 185–193 (2003).
Yushkevich, P. A. et al. User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. NeuroImage 31, 1116–1128 (2006).
Zhu, S. C. & Yuille, A. Region competition: unifying snakes, region growing, and bayes/mdl for multiband image segmentation. IEEE Trans. Pattern Anal. 18, 884–900 (1996).
Sahgal, N., Canham, L. N., Canham, B. & Soares, M. J. Rcho-1 trophoblast stem cells: a model system for studying trophoblast cell differentiation. Methods Mol. Med. 121, 159–178 (2006).
Liu, F., Song, Y. K. & Liu, D. Hydrodynamic-based transfection in animal by systemic administration of plasmid DNA. Gene Ther. 6, 1258–1266 (1999).
Ullah, Z., Kohn, M. J., Yagi, R., Vassilev, L. T. & DePamphilis, M. L. Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity. Gen. Dev. 22, 3204–3236 (2008).
Nagahama, H. et al. Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development. Anat. Embryol. 203, 77–87 (2001).
Schultze, B., Gerhard, H. & Maurer, W. Liver Regeneration after Experimental Injury (Grune and Stratton, 1975).
Kiermayer, C., Conrad, M., Schneider, M., Schmidt, J. & Brielmeier, M. Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate. Genesis 45, 11–16 (2007).