RhoA signalling controls many diverse cellular processes, and thus discovering the mechanisms that determine its specific outcomes is a tantalizing challenge. A previously uncharacterized regulatory module operates selectively at the zonula adherens of epithelial cell junctions, in which positive and negative RhoA regulators are coordinated to fine-tune RhoA activity.
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Kher, S., Worthylake, R. Nuanced junctional RhoA activity. Nat Cell Biol 14, 784–786 (2012). https://doi.org/10.1038/ncb2553
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DOI: https://doi.org/10.1038/ncb2553
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