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FOXOphagy path to inducing stress resistance and cell survival

Nature Cell Biology volume 14, pages 786788 (2012) | Download Citation

Nutrient deprivation and other stress stimuli elicit metabolic changes (such as the induction of autophagy and activation of FOXO transcription factors) that help an organism adapt to stressful conditions. A link between these stress response pathways is revealed by the finding that FOXO3 upregulates the expression of glutamine synthetase to promote glutamine accumulation, inhibit mTOR signalling and promote autophagy.

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Author information

Affiliations

  1. Marco Sandri is in the Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy, the Dulbecco Telethon Institute, Venetian Institute of Molecular Medicine, 35129 Padova, Italy, the Institute of Neuroscience, Consiglio Nazionale delle Ricerche, 35121 Padova, Italy, and the Department of Medicine, McGill University, Montreal, H3A 1A1, Canada

    • Marco Sandri

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Marco Sandri.

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DOI

https://doi.org/10.1038/ncb2550

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