Nutrient deprivation and other stress stimuli elicit metabolic changes (such as the induction of autophagy and activation of FOXO transcription factors) that help an organism adapt to stressful conditions. A link between these stress response pathways is revealed by the finding that FOXO3 upregulates the expression of glutamine synthetase to promote glutamine accumulation, inhibit mTOR signalling and promote autophagy.
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Sandri, M. FOXOphagy path to inducing stress resistance and cell survival. Nat Cell Biol 14, 786–788 (2012). https://doi.org/10.1038/ncb2550
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DOI: https://doi.org/10.1038/ncb2550
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