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Get on the exosome bus with ALIX

Nature Cell Biology volume 14, pages 654655 (2012) | Download Citation

Exosomes have a growing inventory of functions, but the mechanism of protein sorting into exosomes has been unclear. Now, a signal sequence first described in viral budding provides just such a cargo sorting mechanism, revealing closer-than-expected parallelism between exosome biogenesis and the ESCRT-dependent endolysosomal pathway.

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Author information

Affiliations

  1. James H. Hurley is at the Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA

    • James H. Hurley
  2. Greg Odorizzi is at the Department of Molecular, Cell and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA

    • Greg Odorizzi

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  1. Search for James H. Hurley in:

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to James H. Hurley or Greg Odorizzi.

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DOI

https://doi.org/10.1038/ncb2530

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