Exosomes have a growing inventory of functions, but the mechanism of protein sorting into exosomes has been unclear. Now, a signal sequence first described in viral budding provides just such a cargo sorting mechanism, revealing closer-than-expected parallelism between exosome biogenesis and the ESCRT-dependent endolysosomal pathway.
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Hurley, J., Odorizzi, G. Get on the exosome bus with ALIX. Nat Cell Biol 14, 654–655 (2012). https://doi.org/10.1038/ncb2530
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DOI: https://doi.org/10.1038/ncb2530
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