The transcription factor Twist1 is overexpressed in tumours and can induce the epithelial–mesenchymal transition, resulting in increased invasiveness. Twist1 is now shown to regulate cancer cell migration and invasion in three-dimensional environments by activating the RAC1 GTPase through suppression of a let-7 microRNA family member.
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Childs, G., Segall, J. Twists and turns of invasion. Nat Cell Biol 14, 337–339 (2012). https://doi.org/10.1038/ncb2477
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DOI: https://doi.org/10.1038/ncb2477
