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A numbers game underpins cytoplasmic mRNA transport

Nature Cell Biology volume 14, pages 333–335 (2012)Cite this article

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Microtubule-based mRNA transport participates in the establishment of cell asymmetries. An in vitro reconstitution assay demonstrates that localization signals present in an mRNA influence motor copy number on single RNA molecule cargoes, ultimately leading to highly polarized distributions of transcripts.

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Figure 1: Dynein-dependent RNA localization in the Drosophila syncytial blastoderm.

References

  1. Martin, K. C. & Ephrussi, A. Cell 136, 719–730 (2009).

    Article  CAS  Google Scholar 

  2. Holt, C. E. & Bullock, S. L. Science 326, 1212–1216 (2009).

    Article  CAS  Google Scholar 

  3. Wilkie, G. S. & Davis, I. Cell 105, 209–219 (2001).

    Article  CAS  Google Scholar 

  4. Bullock, S. L., Nicol, A., Gross, S. P. & Zicha, D. Curr. Biol. 16, 1447–1452 (2006).

    Article  CAS  Google Scholar 

  5. Amrute-Nayak, M. & Bullock, S. L. Nat. Cell Biol. 14, 416–423 (2012).

    Article  CAS  Google Scholar 

  6. Allen, R. D. et al. J. Cell Biol. 100, 1736–1752 (1985).

    Article  CAS  Google Scholar 

  7. Vale, R. D., Schnapp, B. J., Reese, T. S. & Sheetz, M. P. Cell 40, 559–569 (1985).

    Article  CAS  Google Scholar 

  8. Chung, S. & Takizawa, P. A. J. Cell Biol. 189, 755–767 (2010).

    Article  CAS  Google Scholar 

  9. Serano, T. L., Karlin-McGinness, M. & Cohen, R. S. Mech. Dev. 51, 183–192 (1995).

    Article  CAS  Google Scholar 

  10. Lange, S. et al. Traffic 9, 1256–1267 (2008).

    Article  CAS  Google Scholar 

  11. Gao, Y., Tatavarty, V., Korza, G., Levin, M. K. & Carson, J. H. Mol. Biol. Cell 19, 2311–2327 (2008).

    Article  CAS  Google Scholar 

  12. Mikl, M., Vendra, G. & Kiebler, M. A. EMBO Rep. 12, 1077–1084 (2011).

    Article  CAS  Google Scholar 

  13. Chekulaeva, M., Hentze, M. W. & Ephrussi, A. Cell 124, 521–533 (2006).

    Article  CAS  Google Scholar 

  14. Ross, J. L., Wallace, K., Shuman, H., Goldman, Y. E. & Holzbaur, E. L. Nat. Cell Biol. 8, 562–570 (2006).

    Article  CAS  Google Scholar 

  15. Zimyanin, V. L. et al. Cell 134, 843–853 (2008).

    Article  CAS  Google Scholar 

  16. Bullock, S. L. Semin. Cell Dev. Biol. 18, 194–201 (2007).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Michael Doyle and Michael A. Kiebler are at the Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria,

    Michael Doyle & Michael A. Kiebler

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  1. Michael Doyle
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  2. Michael A. Kiebler
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Correspondence to Michael A. Kiebler.

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The authors declare no competing financial interests.

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Doyle, M., Kiebler, M. A numbers game underpins cytoplasmic mRNA transport. Nat Cell Biol 14, 333–335 (2012). https://doi.org/10.1038/ncb2475

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