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Secreted miRNAs suppress atherogenesis

Endothelial–vascular smooth muscle cell communication has a critical role in cardiovascular homeostasis and the pathogenesis of atherosclerosis. A study now demonstrates extracellular-vesicle-mediated transfer of the atheroprotective microRNAs miR-143/145 between endothelial and vascular smooth muscle cells, providing compelling evidence that intercellular transport of miRNAs can influence a pathological process, namely atherosclerosis.

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Figure 1: Endothelial–VSMC communication through extracellular vesicles of atheroprotective miRNAs.

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Correspondence to Daniel J. Rader.

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Rader, D., Parmacek, M. Secreted miRNAs suppress atherogenesis. Nat Cell Biol 14, 233–235 (2012). https://doi.org/10.1038/ncb2452

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