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Pik1-ing clathrin adaptors

Nature Cell Biology volume 14, pages 231–232 (2012)Cite this article

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Clathrin adaptor proteins are essential for clathrin-coated vesicle biogenesis, yet the mechanisms governing their recruitment and interactions remain incompletely defined. The clathrin adaptors Gga and AP-1 are now shown to be recruited sequentially to the trans-Golgi network in two waves of clathrin coat assembly, coupled by Pik1-mediated phosphatidylinositol-4-phosphate synthesis. These findings reveal mechanistic insights into the functional and regulatory relationships between these clathrin adaptors.

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Figure 1: Sequential progression of clathrin adaptors at the TGN.

References

  1. Bonifacino, J. S. Nat. Rev. Mol. Cell Biol. 5, 23–32 (2004).

    Article  CAS  Google Scholar 

  2. Doray, B. et al. Science 297, 1700–1703 (2002).

    Article  CAS  Google Scholar 

  3. Hinners, I. & Tooze, S. A. J. Cell Sci. 116, 763–771 (2003).

    Article  CAS  Google Scholar 

  4. Robinson, M. S. Trends Cell Biol. 14, 167–174 (2004).

    Article  CAS  Google Scholar 

  5. Daboussi, L. et al. Nat. Cell Biol. 14, 239–248 (2012).

    Article  CAS  Google Scholar 

  6. Hirst, J. et al. Traffic 10, 1696–1710 (2009).

    Article  CAS  Google Scholar 

  7. Puertollano, R. et al. Mol. Biol. Cell 14, 1545–1557 (2003).

    Article  CAS  Google Scholar 

  8. Waguri, S. et al. Mol. Biol. Cell 14, 142–155 (2003).

    Article  CAS  Google Scholar 

  9. Losev, E. et al. Nature 441, 1002–1006 (2006).

    Article  CAS  Google Scholar 

  10. Tokita, M. et al. Nature 441, 1007–1010 (2006).

    Article  Google Scholar 

  11. Schermelleh, L. et al. Science 320, 1332–1336 (2008).

    Article  CAS  Google Scholar 

  12. Demmel, L. et al. Mol. Biol. Cell 19, 1991–2002 (2008).

    Article  CAS  Google Scholar 

  13. Wang, J. et al. Mol. Biol. Cell 18, 2646–2655 (2007).

    Article  CAS  Google Scholar 

  14. Wang, Y. J. et al. Cell 114, 299–310 (2003).

    Article  CAS  Google Scholar 

  15. Zoncu, R. et al. Cell 136, 1110–1121 (2009).

    Article  CAS  Google Scholar 

  16. Weinberg, J. & Drubin, D. G. Trends Cell Biol. 22, 1–13 (2012).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Yidi Sun and David G. Drubin are at the Department of Molecular and Cell Biology, University of California Berkeley, California 94720-3202, USA,

    Yidi Sun & David G. Drubin

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  1. Yidi Sun
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  2. David G. Drubin
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Correspondence to David G. Drubin.

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The authors declare no competing financial interests.

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Sun, Y., Drubin, D. Pik1-ing clathrin adaptors. Nat Cell Biol 14, 231–232 (2012). https://doi.org/10.1038/ncb2448

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