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Navigating the ERAD interaction network

The endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway, which orchestrates the degradation of ER proteins by the proteasome, involves a plethora of proteins with diverse functions. Using a combination of proteomic and genetic approaches, a recent study provides fresh insights into the organization of the mammalian ERAD interaction network and the functions of its components.

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Figure 1: Mapping the ERAD interaction network.

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Correspondence to Thibault Mayor.

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Mayor, T. Navigating the ERAD interaction network. Nat Cell Biol 14, 46–47 (2012). https://doi.org/10.1038/ncb2412

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