Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Navigating the ERAD interaction network

The endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway, which orchestrates the degradation of ER proteins by the proteasome, involves a plethora of proteins with diverse functions. Using a combination of proteomic and genetic approaches, a recent study provides fresh insights into the organization of the mammalian ERAD interaction network and the functions of its components.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Mapping the ERAD interaction network.


  1. Vembar, S. S. & Brodsky, J. L. Nat. Rev. Mol. Cell Biol. 9, 944–957 (2008).

    Article  CAS  Google Scholar 

  2. Christianson, J. C. et al. Nat. Cell Biol. 14, 93–105 (2012).

    Article  CAS  Google Scholar 

  3. Cheng, S. H. et al. Cell 63, 827–834 (1990).

    Article  CAS  Google Scholar 

  4. Carvalho, P., Goder, V. & Rapoport, T. A. Cell 126, 361–373 (2006).

    Article  CAS  Google Scholar 

  5. Denic, V., Quan, E. M. & Weissman, J. S. Cell 126, 349–359 (2006).

    Article  CAS  Google Scholar 

  6. Claessen, J. H., Kundrat, L. & Ploegh, H. L. Trends Cell Biol. (2011).

  7. Bernasconi, R. et al. J. Cell Biol. 188, 223–235 (2010).

    Article  CAS  Google Scholar 

  8. Okuda-Shimizu, Y. & Hendershot, L. M. Mol. Cell 28, 544–554 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Thibault Mayor.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mayor, T. Navigating the ERAD interaction network. Nat Cell Biol 14, 46–47 (2012).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing