The endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway, which orchestrates the degradation of ER proteins by the proteasome, involves a plethora of proteins with diverse functions. Using a combination of proteomic and genetic approaches, a recent study provides fresh insights into the organization of the mammalian ERAD interaction network and the functions of its components.
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References
Vembar, S. S. & Brodsky, J. L. Nat. Rev. Mol. Cell Biol. 9, 944–957 (2008).
Christianson, J. C. et al. Nat. Cell Biol. 14, 93–105 (2012).
Cheng, S. H. et al. Cell 63, 827–834 (1990).
Carvalho, P., Goder, V. & Rapoport, T. A. Cell 126, 361–373 (2006).
Denic, V., Quan, E. M. & Weissman, J. S. Cell 126, 349–359 (2006).
Claessen, J. H., Kundrat, L. & Ploegh, H. L. Trends Cell Biol. http://dx.doi.org/10.1016/j.tcb.2011.09.010 (2011).
Bernasconi, R. et al. J. Cell Biol. 188, 223–235 (2010).
Okuda-Shimizu, Y. & Hendershot, L. M. Mol. Cell 28, 544–554 (2007).
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Mayor, T. Navigating the ERAD interaction network. Nat Cell Biol 14, 46–47 (2012). https://doi.org/10.1038/ncb2412
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DOI: https://doi.org/10.1038/ncb2412
