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Pulling together and pulling apart: collective cargo movement in eukaryotic cells

Nature Cell Biology volume 13, pages 1391–1392 (2011)Cite this article

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To establish and maintain their internal organization, living cells must move molecules to their correct locations. Long-range intracellular movements are often driven by motor molecules moving along microtubules, similarly to trucks driving along a highway. Recent work demonstrates that some randomly dispersed cargos can generate actin filaments that form a connected network whose contraction drives collective cargo movement.

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Figure 1: Movement of intracellular cargo.
Figure 2: Geometry of contraction-driven cargo movements in various cell types.

References

  1. Schuh, M. Nat. Cell Biol. 13, 1431–1436 (2011).

    Article  CAS  Google Scholar 

  2. Roy, S., Hsiung, F. & Kornberg, T. B. Science 332, 354–358 (2011).

    Article  CAS  Google Scholar 

  3. Lénárt, P., Bacher, C. P., Daigle, N., Hand, A. R., Eils, R., Terasaki, M. & Ellenberg, J. Nature 436, 812–818 (2005).

    Article  Google Scholar 

  4. Quinlan, M. E., Hilgert, S., Bedrossian, A., Mullins, R. D. & Kerkhoff, E. J. Cell Biol. 179, 117–128 (2007).

    Article  CAS  Google Scholar 

  5. Pfender, S., Kuznetsov, V., Pleiser, S., Kerkhoff, E. & Schuh, M. Curr. Biol. 21, 955–960 (2011).

    Article  CAS  Google Scholar 

  6. Pollard, T. D., Blanchoin, L. & Mullins, R. D. Annu. Rev. Biophys. Biomol. Struct. 29, 545–576 (2000).

    Article  CAS  Google Scholar 

  7. Tanaka, T., Kato, Y., Matsuda, K., Hanyu-Nakamura, K. & Nakamura, A. Development. 138, 2523–2532 (2011).

    Article  CAS  Google Scholar 

  8. Krauss, J., López de Quinto, S., Nüsslein-Volhard, C. & Ephrussi, A. Curr. Biol. 19, 1058–1063 (2009).

    Article  CAS  Google Scholar 

  9. Munro, E. & Bowerman, B. Cold Spring Harb. Perspect. Biol. 1 (4), a003400 (2009).

    Article  Google Scholar 

Download references

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  1. Dyche Mullins is at the Department of Cellular and Molecular Pharmacology, University of California San Fransisco, 600 16th Street, N312F Genentech Hall, San Francisco, California 94158, USA,

    Dyche Mullins

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  1. Dyche Mullins
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Correspondence to Dyche Mullins.

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Mullins, D. Pulling together and pulling apart: collective cargo movement in eukaryotic cells. Nat Cell Biol 13, 1391–1392 (2011). https://doi.org/10.1038/ncb2393

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