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A new cap for kinetochore fibre minus ends

In mitotic spindles, each sister chromatid is directly attached to a spindle pole through microtubule bundles known as kinetochore fibres. Microspherule protein 1 (MCRS1) is now shown to support spindle assembly by localizing to the minus ends of kinetochore fibres and protecting them from depolymerization.

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Figure 1: MCRS1 has multiple functions in interphase and mitosis.

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Correspondence to Ronald D. Vale.

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Petry, S., Vale, R. A new cap for kinetochore fibre minus ends. Nat Cell Biol 13, 1389–1391 (2011). https://doi.org/10.1038/ncb2387

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