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Shaping development with ESCRTs

Nature Cell Biology volume 14, pages 38–45 (2012)Cite this article

Abstract

Originally identified for their involvement in endosomal sorting and multivesicular endosome (MVE) biogenesis, components of the endosomal sorting complex required for transport (ESCRT) are now known to control additional cellular functions such as receptor signalling, cytokinesis, autophagy, polarity, migration, miRNA activity and mRNA transport. The diverse cell biological functions of ESCRT proteins are translated into a pleiotropic set of developmental trajectories that reflect the wide repertoire of these evolutionarily conserved proteins.

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Figure 1: The ESCRT machinery in endosomal sorting and MVE biogenesis.
Figure 2: Cell biological processes regulated by ESCRTs.
Figure 3: The ESCRT machinery in developmental processes.

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Acknowledgements

T.E.R. is an investigator of the Norwegian Cancer Society. T.V. acknowledges funding from Associazione Italiana per la Ricerca sul Cancro. H.S. thanks the Research Council of Norway, the South-Eastern Norway Regional Health Authority, and the European Research Council for financial support.

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Authors and Affiliations

  1. Norway and also in the Department of Biochemistry, Tor Erik Rusten and Harald Stenmark are at the Centre for Cancer Biomedicine, Faculty of Medicine, Oslo University Hospital, Montebello, 0310 Oslo, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway,

    Tor Erik Rusten & Harald Stenmark

  2. Thomas Vaccari is at the Istituto FIRC di Oncologia Molecolare, via Adamello 16, 20139, Milano, Italy,

    Thomas Vaccari

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Correspondence to Harald Stenmark.

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Rusten, T., Vaccari, T. & Stenmark, H. Shaping development with ESCRTs. Nat Cell Biol 14, 38–45 (2012). https://doi.org/10.1038/ncb2381

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