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esBAF safeguards Stat3 binding to maintain pluripotency

Nature Cell Biology volume 13, pages 886888 (2011) | Download Citation

How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).

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Affiliations

  1. Noa Novershtern and Jacob H. Hanna are at The Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel

    • Noa Novershtern
    •  & Jacob H. Hanna

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The authors declare no competing financial interests.

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Correspondence to Noa Novershtern or Jacob H. Hanna.

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DOI

https://doi.org/10.1038/ncb2311

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