How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Regulation of germ layer formation by pluripotency factors during embryogenesis
Cell & Bioscience Open Access 11 March 2013
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hanna, J. H., Saha, K. & Jaenisch, R. Cell 143, 508–525 (2010).
Tchieu, J. et al. Cell Stem Cell 7, 329–342 (2010).
Meshorer, E. & Misteli, T. Nat. Rev. Mol. Cell Biol. 7, 540–546 (2006).
Yamanaka, S. & Blau, H. M. Nature 465, 704–712 (2010).
Yang, J. et al. Cell Stem Cell 7, 319–328 (2010).
Kim, J., Chu, J., Shen, X., Wang, J. & Orkin, S. H. Cell 132, 1049–1061 (2008).
Ho, L. et al. Nat. Cell Biol. 13, 903–913 (2011).
Fazzio, T. G. & Panning, B. Curr. Opin. Genet. Dev. 20, 500–504 (2010).
Ho, L. et al. Proc. Natl Acad. Sci. USA 106, 5181–5186 (2009).
Ho, L. et al. Proc. Natl Acad. Sci. USA 106, 5187–5191 (2009).
Surface, L. E., Thornton, S. R. & Boyer, L. A. Cell Stem Cell 7, 288–298 (2010).
Bao, S. et al. Nature 461, 1292–1295 (2009).
Hanna, J. et al. Proc. Natl Acad. Sci. USA 107, 9222–9227 (2010).
Ying, Q. L. et al. Nature 453, 519–523 (2008).
Madhani, H. D. et al. Science 322, 43–44 (2008).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Novershtern, N., Hanna, J. esBAF safeguards Stat3 binding to maintain pluripotency. Nat Cell Biol 13, 886–888 (2011). https://doi.org/10.1038/ncb2311
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb2311
This article is cited by
-
Regulation of germ layer formation by pluripotency factors during embryogenesis
Cell & Bioscience (2013)