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Mammalian Rap1 widens its impact

Nature Cell Biology volume 12, pages 733735 (2010) | Download Citation

Three recent studies reveal unexpected functions of Rap1, a member of the shelterin complex that protects chromosome ends from the activity of DNA repair pathways. Rap1 not only protects telomeres from sister chromatid exchange, but also functions in genome-wide transcriptional regulation and NF-κB-dependent signalling, revealing new perspectives for the telomere field.

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Author information

Affiliations

  1. Laure Crabbe and Jan Karlseder are in the Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

    • Laure Crabbe
    •  & Jan Karlseder

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Jan Karlseder.

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DOI

https://doi.org/10.1038/ncb2088

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