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Mammalian Rap1 widens its impact

Three recent studies reveal unexpected functions of Rap1, a member of the shelterin complex that protects chromosome ends from the activity of DNA repair pathways. Rap1 not only protects telomeres from sister chromatid exchange, but also functions in genome-wide transcriptional regulation and NF-κB-dependent signalling, revealing new perspectives for the telomere field.

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Figure 1: Rap1 might link telomere length to NF-κB signalling.

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Correspondence to Jan Karlseder.

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Crabbe, L., Karlseder, J. Mammalian Rap1 widens its impact. Nat Cell Biol 12, 733–735 (2010). https://doi.org/10.1038/ncb2088

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