Three recent studies reveal unexpected functions of Rap1, a member of the shelterin complex that protects chromosome ends from the activity of DNA repair pathways. Rap1 not only protects telomeres from sister chromatid exchange, but also functions in genome-wide transcriptional regulation and NF-κB-dependent signalling, revealing new perspectives for the telomere field.
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Crabbe, L., Karlseder, J. Mammalian Rap1 widens its impact. Nat Cell Biol 12, 733–735 (2010). https://doi.org/10.1038/ncb2088
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DOI: https://doi.org/10.1038/ncb2088
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Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
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