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Nuclear transport receptor goes moonlighting

Nature Cell Biology volume 12, pages 640–641 (2010)Cite this article

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The importin-β-like transport receptors and RanGTP govern selective transport of proteins into the nucleus. It has now been shown that importin-β2 (alternatively called transportin1) also selectively targets the motor protein Kif17 to primary cilia. In analogy to the nucleus, RanGTP in the intraciliary compartment mediates dissociation of Kif17 from its transport receptor and thereby completes import.

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Figure 1: Importin-β2 mediates the ciliary targeting of the microtubule motor KIF17.

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  1. Oliver J. Gruss is in the Zentrum für Molekulare Biologie, ZMBH, DKFZ ZMBH Alliance, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany. o.gruss@zmbh.uni-heidelberg.de,

    Oliver J. Gruss

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Gruss, O. Nuclear transport receptor goes moonlighting. Nat Cell Biol 12, 640–641 (2010). https://doi.org/10.1038/ncb2076

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