Kirkwood, T. B. Understanding the odd science of aging. Cell 120, 437–447 (2005).
Kirkwood, T. B. & Cremer, T. Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress. Hum. Genet. 60, 101–121 (1982).
Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H. & Vijg, J. Aging and genome maintenance: lessons from the mouse? Science 299, 1355–1359 (2003).
Lombard, D. B. et al. DNA repair, genome stability, and aging. Cell 120, 497–512 (2005).
Campisi, J. Aging, tumor suppression and cancer: high wire-act! Mech. Ageing Dev. 126, 51–58 (2005).
Schumacher, B., Garinis, G. A. & Hoeijmakers, J. H. Age to survive: DNA damage and aging. Trends Genet. 24, 77–85 (2008).
Sedelnikova, O. A. et al. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nature Cell Biol. 6, 168–170 (2004).
Dolle, M. E. et al. Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nature Genet. 17, 431–434 (1997).
Sedelnikova, O. A. et al. Delayed kinetics of DNA double-strand break processing in normal and pathological aging. Aging Cell 7, 89–100 (2008).
Herndon, L. A. et al. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808–814 (2002).
Rea, S. L., Wu, D., Cypser, J. R., Vaupel, J. W. & Johnson, T. E. A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nat Genet 37, 894–898 (2005).
Kenyon, C. The plasticity of aging: insights from long-lived mutants. Cell 120, 449–460 (2005).
Gems, D. Longevity and ageing in parasitic and free-living nematodes. Biogerontology 1, 289–307 (2000).
Guarente, L. & Kenyon, C. Genetic pathways that regulate ageing in model organisms. Nature 408, 255–262 (2000).
Giannakou, M. E. & Partridge, L. Role of insulin-like signalling in Drosophila lifespan. Trends Biochem. Sci. 32, 180–188 (2007).
Carter, C. S., Ramsey, M. M. & Sonntag, W. E. A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends Genet. 18, 295–301 (2002).
Holzenberger, M. et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182–187 (2003).
Kurosu, H. et al. Suppression of aging in mice by the hormone Klotho. Science 309, 1829–1833 (2005).
Bonkowski, M. S. et al. Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics. J. Gerontol. A Biol. Sci. Med. Sci. 61, 562–567 (2006).
Bartke, A. & Brown-Borg, H. Life extension in the dwarf mouse. Curr. Top. Dev. Biol. 63, 189–225 (2004).
Niedernhofer, L. J. et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 444, 1038–1043 (2006).
Ramirez, C. L., Cadinanos, J., Varela, I., Freije, J. M. & Lopez-Otin, C. Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell Mol. Life Sci. 64, 155–170 (2007).
Garinis, G. A., van der Horst, G. T., Vijg, J. & Hoeijmakers, J. H. DNA damage and ageing: new-age ideas for an age-old problem. Nature Cell Biol. 10, 1241–1247 (2008).
Lehmann, A. R. DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. Biochimie 85, 1101–1111 (2003).
van der Pluijm, I. et al. Impaired genome maintenance suppresses the growth hormone–insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol. 5, e2 (2006).
Masternak, M. M. et al. Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice. Exp. Gerontol. 40, 679–684 (2005).
van Hoffen, A., Venema, J., Meschini, R., van Zeeland, A. A. & Mullenders, L. H. Transcription-coupled repair removes both cyclobutane pyrimidine dimers and 6-4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts. EMBO J. 14, 360–367 (1995).
Tsuchiya, T. et al. Additive regulation of hepatic gene expression by dwarfism and caloric restriction. Physiol. Genomics 17, 307–315 (2004).
Rowland, J. E. et al. In vivo analysis of growth hormone receptor signaling domains and their associated transcripts. Mol. Cell. Biol. 25, 66–77 (2005).
Boylston, W. H. et al. Altered cholesterologenic and lipogenic transcriptional profile in livers of aging Snell dwarf (Pit1dw/dwJ) mice. Aging Cell 3, 283–296 (2004).
Schumacher, B. et al. Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet 4, e1000161 (2008).
Liang, H. et al. Genetic mouse models of extended lifespan. Exp. Gerontol. 38, 1353–1364 (2003).
Verma, A. K., Wheeler, D. L., Aziz, M. H. & Manoharan, H. Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer. Mol. Carcinog. 45, 381–388 (2006).
Stachelscheid, H. et al. Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation. EMBO J. 27, 2091–2101 (2008).
Piwien-Pilipuk, G., Huo, J. S. & Schwartz, J. Growth hormone signal transduction. J. Pediatr. Endocrinol. Metab. 15, 771–786 (2002).
Partridge, L. & Gems, D. Mechanisms of ageing: public or private? Nature Rev. Genet. 3, 165–175 (2002).
Salmon, A. B. et al. Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am. J. Physiol. Endocrinol. Metab. 289, E23–E29 (2005).
O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A. & Goodship, J. A. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nature Genet. 33, 497–501 (2003).
Nunez, F., Chipchase, M. D., Clarke, A. R. & Melton, D. W. Nucleotide excision repair gene (ERCC1) deficiency causes G2 arrest in hepatocytes and a reduction in liver binucleation: the role of p53 and p21. FASEB J. 14, 1073–1082 (2000).
Abraham, R. T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15, 2177–2196 (2001).
Dizdaroglu, M. Base-excision repair of oxidative DNA damage by DNA glycosylases. Mutat. Res. 591, 45–59 (2005).
Dianov, G. L. & Parsons, J. L. Co-ordination of DNA single strand break repair. DNA Repair 6, 454–460 (2007).
DiBiase, S. J. et al. DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus. Cancer Res. 60, 1245–1253 (2000).
Essers, J. et al. Dynamics of relative chromosome position during the cell cycle. Mol. Biol. Cell 16, 769–775 (2005).
Garinis, G. A. et al. Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks. EMBO J. 24, 3952–3962 (2005).
You, Y. H. et al. Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells. J. Biol. Chem. 276, 44688–44694 (2001).
Mellon, I., Spivak, G. & Hanawalt, P. C. Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene. Cell 51, 241–249 (1987).
Bohr, V. A., Smith, C. A., Okumoto, D. S. & Hanawalt, P. C. DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell 40, 359–369 (1985).
Riou, L. et al. Differential repair of the two major UV-induced photolesions in trichothiodystrophy fibroblasts. Cancer Res. 64, 889–894 (2004).
Jaspers, N. G. et al. Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair 1, 1027–1038 (2002).
Fousteri, M., Vermeulen, W., van Zeeland, A. A. & Mullenders, L. H. Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo. Mol. Cell 23, 471–482 (2006).
Jans, J. et al. Powerful skin cancer protection by a CPD-photolyase transgene. Curr. Biol. 15, 105–115 (2005).
Dardevet, D., Sornet, C., Attaix, D., Baracos, V. E. & Grizard, J. Insulin-like growth factor-1 and insulin resistance in skeletal muscles of adult and old rats. Endocrinology 134, 1475–1484 (1994).
Rivera, E. J. et al. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J. Alzheimers Dis. 8, 247–268 (2005).
Li, M., Li, C. & Parkhouse, W. S. Age-related differences in the des IGF-I-mediated activation of Akt-1 and p70 S6K in mouse skeletal muscle. Mech. Ageing Dev. 124, 771–778 (2003).
Charlet-Berguerand, N. et al. RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors. EMBO J. 25, 5481–5491 (2006).
Brooks, P. J. The case for 8,5′-cyclopurine-2′-deoxynucleosides as endogenous DNA lesions that cause neurodegeneration in xeroderma pigmentosum. Neuroscience 145, 1407–1417 (2007).
Wijnhoven, S. W. et al. Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction. DNA Repair 4, 1314–1324 (2005).
Paci, A. et al. Pharmacokinetics, metabolism, and routes of excretion of intravenous irofulven in patients with advanced solid tumors. Drug. Metab. Dispos. 34, 1918–1926 (2006).
Hartog, H., Wesseling, J., Boezen, H. M. & van der Graaf, W. T. The insulin-like growth factor 1 receptor in cancer: old focus, new future. Eur. J. Cancer 43, 1895–1904 (2007).
Vermeulen, C. J. & Loeschcke, V. Longevity and the stress response in Drosophila. Exp. Gerontol. 42, 153–159 (2007).
Daitoku, H. & Fukamizu, A. FOXO transcription factors in the regulatory networks of longevity. J. Biochem. 141, 769–774 (2007).
Doonan, R. et al. Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev. 22, 3236–3241 (2008).
Murakami, S. Stress resistance in long-lived mouse models. Exp. Gerontol. 41, 1014–1019 (2006).
Gems, D. & Partridge, L. Stress-response hormesis and aging: “that which does not kill us makes us stronger”. Cell Metab. 7, 200–203 (2008).
Nouspikel, T. & Hanawalt, P. C. DNA repair in terminally differentiated cells. DNA Repair 1, 59–75 (2002).
Ljungman, M. & Lane, D. P. Transcription — guarding the genome by sensing DNA damage. Nature Rev. Cancer 4, 727–737 (2004).
Kirkwood, T. Repair and its Evolution: Survival Versus Reproduction 165–189 (Blackwell, 1981).
Teuling, E. et al. Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates. J. Neurosci. 27, 9801–9815 (2007).
Ford, J. M. & Hanawalt, P. C. Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts. J. Biol. Chem. 272, 28073–28080 (1997).
Pfaffl, M. W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29, e45 (2001).