Reed, S.I. Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover. Nature Rev. Mol. Cell Biol. 4, 855–864 (2003).
Nakayama, K.I. & Nakayama, K. Ubiquitin ligases: cell-cycle control and cancer. Nature Rev. Cancer 6, 369–381 (2006).
Cardozo, T. & Pagano, M. The SCF ubiquitin ligase: insights into a molecular machine. Nature Rev. Mol. Cell Biol. 5, 739–751 (2004).
Harper, J.W., Burton, J.L. & Solomon, M.J. The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 16, 2179–2206 (2002).
Peters, J.M. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nature Rev. Mol. Cell Biol. 7, 644–656 (2006).
Acquaviva, C. & Pines, J. The anaphase-promoting complex/cyclosome: APC/C. J. Cell Sci. 119, 2401–2404 (2006).
Pines, J. Mitosis: a matter of getting rid of the right protein at the right time. Trends Cell Biol. 16, 55–63 (2006).
Sullivan, M. & Morgan, D.O. Finishing mitosis, one step at a time. Nature Rev. Mol. Cell Biol. 8, 894–903 (2007).
Bashir, T., Dorrello, N.V., Amador, V., Guardavaccaro, D. & Pagano, M. Control of the SCF(Skp2–Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature 428, 190–193 (2004).
Wei, W. et al. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 428, 194–198 (2004).
Vodermaier, H.C. APC/C and SCF: controlling each other and the cell cycle. Curr. Biol. 14, R787–R796 (2004).
Ang, X.L. & Harper, J.W. Interwoven ubiquitination oscillators and control of cell cycle transitions. Sci. STKE 2004, pe31 (2004).
Carter, S.L., Eklund, A.C., Kohane, I.S., Harris, L.N. & Szallasi, Z. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nature Genet. 38, 1043–1048 (2006).
Cross, J.C. How to make a placenta: mechanisms of trophoblast cell differentiation in mice--a review. Placenta 26 (suppl. A), S3–S9 (2005).
Hayashi, S., Lewis, P., Pevny, L. & McMahon, A.P. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech. Dev. 119 (suppl 1), S97–S101 (2002).
Prinz, S., Hwang, E.S., Visintin, R. & Amon, A. The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis. Curr. Biol. 8, 750–760 (1998).
Shirayama, M., Zachariae, W., Ciosk, R. & Nasmyth, K. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J. 17, 1336–1349 (1998).
Gieffers, C., Peters, B.H., Kramer, E.R., Dotti, C.G. & Peters, J.M. Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. Proc. Natl Acad. Sci. USA 96, 11317–11322 (1999).
Konishi, Y., Stegmuller, J., Matsuda, T., Bonni, S. & Bonni, A. Cdh1–APC controls axonal growth and patterning in the mammalian brain. Science 303, 1026–1030 (2004).
Alvarez-Buylla, A. & Garcia-Verdugo, J.M. Neurogenesis in adult subventricular zone. J. Neurosci. 22, 629–634 (2002).
Ferri, A.L. et al. Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development 131, 3805–3819 (2004).
Visintin, R., Prinz, S. & Amon, A. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278, 460–463 (1997).
Schwab, M., Lutum, A.S. & Seufert, W. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis. Cell 90, 683–693 (1997).
Yamaguchi, S., Murakami, H. & Okayama, H. A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes. Mol. Biol. Cell 8, 2475–2486 (1997).
Kitamura, K., Maekawa, H. & Shimoda, C. Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase. Mol. Biol. Cell 9, 1065–1080 (1998).
Fay, D.S., Keenan, S. & Han, M. fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen. Genes Dev. 16, 503–517 (2002).
Sigrist, S.J. & Lehner, C.F. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 90, 671–681 (1997).
Strausfeld, U.P. et al. Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts. J. Cell Sci. 109 (Pt 6), 1555–1563 (1996).
Moore, J.D., Kirk, J.A. & Hunt, T. Unmasking the S-phase-promoting potential of cyclin B1. Science 300, 987–990 (2003).
Engelbert, D., Schnerch, D., Baumgarten, A. & Wasch, R. The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells. Oncogene 27, 907–917 (2008).
Sudo, T. et al. Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells. EMBO J. 20, 6499–6508 (2001).
Perez de Castro, I., de Carcer, G. & Malumbres, M. A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy. Carcinogenesis 28, 899–912 (2007).
Karakaidos, P. et al. Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability-evidence of E2F-1 transcriptional control over hCdt1. Am. J. Pathol. 165, 1351–1365 (2004).
Pinyol, M. et al. Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instability. Int. J. Cancer 119, 2768–2774 (2006).
DePinho, R.A. The age of cancer. Nature 408, 248–254 (2000).
Weaver, B.A., Silk, A.D., Montagna, C., Verdier-Pinard, P. & Cleveland, D.W. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 11, 25–36 (2007).
Wang, C.X., Fisk, B.C., Wadehra, M., Su, H. & Braun, J. Overexpression of murine fizzy-related (fzr) increases natural killer cell-mediated cell death and suppresses tumor growth. Blood 96, 259–263 (2000).
Almeida, A., Bolanos, J.P. & Moreno, S. Cdh1/Hct1–APC is essential for the survival of postmitotic neurons. J. Neurosci. 25, 8115–8121 (2005).
Nait-Oumesmar, B. et al. Activation of the subventricular zone in multiple sclerosis: evidence for early glial progenitors. Proc. Natl Acad. Sci. USA 104, 4694–4699 (2007).
Rodriguez, C.I. et al. High-efficiency deleter mice show that FLPe is an alternative to Cre–loxP. Nature Genet. 25, 139–140 (2000).
Schwenk, F., Baron, U. & Rajewsky, K. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23, 5080–5081 (1995).
Malumbres, M. et al. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 118, 493–504 (2004).
Mendez, J. & Stillman, B. Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol. Cell Biol. 20, 8602–8612 (2000).
Quereda, V., Martinalbo, J., Dubus, P., Carnero, A. & Malumbres, M. Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression. Oncogene 26, 7665–7674 (2007).
Miquel, J. & Blasco, M. A simple technique for evaluation of vitality loss in aging mice, by testing their muscular coordination and vigor. Exp. Gerontol. 13, 389–396 (1978).
Bevins, R.A. & Besheer, J. Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'. Nature Protoc. 1, 1306–1311 (2006).