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Directionality of F-actin cables changes during the fission yeast cell cycle

Nature Cell Biology volume 7, pages 916917 (2005) | Download Citation

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Abstract

Longitudinal F-actin cables are thought to be important for transporting materials for polarized cell growth in fission yeast. We show that most F-actin in the cables is oriented such that the barbed end faces the nearest cell tip during interphase; however, this directionality is reversed during mitosis. These orientations of F-actin ensure proper transport of materials to growing sites during these cell-cycle stages.

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Acknowledgements

We thank J. Usukura and M. Sameshima for help in determining the directionality of F-actin. This study was supported by grants from the Ministry of Education, Science and Culture of Japan.

Author information

Author notes

    • Tomoko Kamasaki

    Present address: Department of Oral Histology, School of Dentistry, Showa University, Tokyo 142-8555, Japan.

    • Ritsuko Arai

    Present address: Department of Chemical Genetics, Riken, Wako, 351-0198, Japan.

Affiliations

  1. Division of Biology, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, 153-8902, Japan.

    • Tomoko Kamasaki
    • , Ritsuko Arai
    •  & Issei Mabuchi
  2. Division of Material and Biological Function Sciences, Graduate School of Science, Japan Women's University, Tokyo, 112-8681, Japan.

    • Tomoko Kamasaki
    •  & Masako Osumi
  3. Instistute of Medical Mycology, Teikyo University, Tokyo, 192-0395, Japan.

    • Masako Osumi

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Issei Mabuchi.

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    Supplementary Information

    Supplementary figures S1 and S2, supplementary table S1 and supplementary methods

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DOI

https://doi.org/10.1038/ncb1295

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