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Under arrest in mitosis: Cdc20 dies twice

The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.

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Figure 1: A model for dual inhibition of Cdc20 by the SAC.

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Fry, A., Yamano, H. Under arrest in mitosis: Cdc20 dies twice. Nat Cell Biol 10, 1385–1387 (2008). https://doi.org/10.1038/ncb1208-1385

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