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Under arrest in mitosis: Cdc20 dies twice

Nature Cell Biology volume 10, pages1385–1387(2008)Cite this article

The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.

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Figure 1: A model for dual inhibition of Cdc20 by the SAC.

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Affiliations

  1. Andrew M. Fry is in the Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK. amf5@le.ac.uk

    Andrew M. Fry

  2. Hiroyuki Yamano is at the Marie Curie Research Institute, Oxted RH8, 0TL, UK. h.yamano@mcri.ac.uk

    Hiroyuki Yamano

Authors
  1. Andrew M. Fry
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  2. Hiroyuki Yamano
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Fry, A., Yamano, H. Under arrest in mitosis: Cdc20 dies twice. Nat Cell Biol 10, 1385–1387 (2008). https://doi.org/10.1038/ncb1208-1385

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