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A TRP channel-steroid marriage

A surprising functional association between TRPM3, a mysterious member of the family of transient receptor potential (TRP) cation channels, and the sulphated version of pregnenolone, 'mother' of all steroid hormones, has been identified.

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Figure 1: A 'marriage' between the transient receptor potential channel TRPM3 and the neurosteroid PS.
Figure 2: TRP channels in pancreatic β-cells.


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Nilius, B., Voets, T. A TRP channel-steroid marriage. Nat Cell Biol 10, 1383–1384 (2008).

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