A TRP channel-steroid marriage

A surprising functional association between TRPM3, a mysterious member of the family of transient receptor potential (TRP) cation channels, and the sulphated version of pregnenolone, 'mother' of all steroid hormones, has been identified.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: A 'marriage' between the transient receptor potential channel TRPM3 and the neurosteroid PS.
Figure 2: TRP channels in pancreatic β-cells.

References

  1. 1

    Mayo, W., Le Moal, M. & Abrous, D. N. Horm. Behav. 40, 215–217 (2001).

    CAS  Article  Google Scholar 

  2. 2

    Vallee, M., Mayo, W. & Le Moal, M. Brain Res. Brain Res. Rev. 37, 301–312 (2001).

    CAS  Article  Google Scholar 

  3. 3

    Vallee, M., George, O., Vitiello, S., Le Moal, M. & Mayo, W. Exp. Gerontol. 39, 1695–1704 (2004).

    CAS  Article  Google Scholar 

  4. 4

    Flood, J. F., Morley, J. E. & Roberts, E. Proc. Natl Acad. Sci. USA 92, 10806–10810 (1995).

    CAS  Article  Google Scholar 

  5. 5

    Shen, W., Mennerick, S., Covey, D. F. & Zorumski, C. F. J. Neurosci. 20, 3571–3579 (2000).

    CAS  Article  Google Scholar 

  6. 6

    Eisenman, L. N., He, Y., Fields, C., Zorumski, C. F. & Mennerick, S. J. Physiol. 550, 679–691 (2003).

    CAS  Article  Google Scholar 

  7. 7

    Horak, M., Vlcek, K., Petrovic, M., Chodounska, H. & Vyklicky, L., Jr . J. Neurosci. 24, 10318–10325 (2004).

    CAS  Article  Google Scholar 

  8. 8

    Kudo, K., Tachikawa, E. & Kashimoto, T. Eur. J. Pharmacol. 456, 19–27 (2002).

    CAS  Article  Google Scholar 

  9. 9

    Wagner et al. Nature Cell Biol. 10, 1421–1430 (2008).

    CAS  Article  Google Scholar 

  10. 10

    Oberwinkler, J. & Phillipp, S. E. Handb. Exp. Pharmacol. 253–267 (2007).

  11. 11

    Ashcroft, F. M. Nature 440, 440–447 (2006).

    CAS  Article  Google Scholar 

  12. 12

    Nilius, B., Owsianik, G., Voets, T. & Peters, J. A. Physiol. Rev. 87, 165–217 (2007).

    CAS  Article  Google Scholar 

  13. 13

    Bicikova, M. et al. Steroids 67, 399–402 (2002).

    CAS  Article  Google Scholar 

  14. 14

    de Peretti, E. et al. Acta Endocrinol. Suppl. 279, 259–263 (1986).

    CAS  Article  Google Scholar 

  15. 15

    Bicikova, M., Tallova, J., Hill, M., Krausova, Z. & Hampl, R. Neurochem. Res. 25, 1623–1627 (2000).

    CAS  Article  Google Scholar 

  16. 16

    Tagawa, N. et al. Clin. Chem. 46, 523–528 (2000).

    CAS  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nilius, B., Voets, T. A TRP channel-steroid marriage. Nat Cell Biol 10, 1383–1384 (2008). https://doi.org/10.1038/ncb1208-1383

Download citation

Further reading